Presence of immunoglobulin (Ig) M and IgG double isotype-bearing cells and defect of switch recombination in hyper IgM immunodeficiency.

We established a transformed B cell line expressing both IgM and IgG on the cell surface from a patient with hyper IgM immunodeficiency using Epstein-Barr viruses. DNA and RNA of the cells were analyzed. DNA rearrangements of Ig JH gene loci were observed on both chromosomes. Cloning and DNA sequenc...

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Publicado en:	J Clin Invest
Autores principales:	Akahori, Y, Kurosawa, Y, Kamachi, Y, Torii, S, Matsuoka, H
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Clinical Investigation 1990
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296632/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2347911/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114627
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