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Molecular Detection of Targeted Major Histocompatibility Complex I-Bound Peptides Using a Probabilistic Measure and Nanospray MS(3) on a Hybrid Quadrupole-Linear Ion Trap

A nanospray MS(3) method deployed on a quadrupole linear ion trap hybrid can detect targeted peptides with high dynamic range and high sensitivity from complex mixtures without separations. The method uses a recognition algorithm that is a modification of the relative (Kullback−Leibler, KL) entropy...

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Autors principals: Reinhold, Bruce, Keskin, Derin B., Reinherz, Ellis L.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2010
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966287/
https://ncbi.nlm.nih.gov/pubmed/20932029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac102387t
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