Excessive Na(+)/H(+) Exchange in Disruption of Dendritic Na(+) and Ca(2+) Homeostasis and Mitochondrial Dysfunction following in Vitro Ischemia

Neuronal dendrites are vulnerable to injury under diverse pathological conditions. However, the underlying mechanisms for dendritic Na(+) overload and the selective dendritic injury remain poorly understood. Our current study demonstrates that activation of NHE-1 (Na(+)/H(+) exchanger isoform 1) in...

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Main Authors: Kintner, Douglas B., Chen, Xinzhi, Currie, Julia, Chanana, Vishal, Ferrazzano, Peter, Baba, Akemichi, Matsuda, Toshio, Cohen, Mike, Orlowski, John, Chiu, Shing-Yan, Taunton, Jack, Sun, Dandan
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Membrane Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966129/
https://ncbi.nlm.nih.gov/pubmed/20817726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.101212
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