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Biochemical and structural insights of the early glycosylation steps in calicheamicin biosynthesis
The enediyne antibiotic calicheamicin (CLM) γ(1)(I) is a prominent antitumor agent that is targeted to DNA by a novel aryltetrasaccharide comprised of an aromatic unit and four unusual carbohydrates. Herein we report the heterologous expression and the biochemical characterization of the two ‘intern...
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| Huvudupphovsmän: | , , , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2008
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2965851/ https://ncbi.nlm.nih.gov/pubmed/18721755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2008.06.011 |
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