A combination of HLA-DQ beta Asp57-negative and HLA DQ alpha Arg52 confers susceptibility to insulin-dependent diabetes mellitus.

Family and population studies indicate that predisposition to insulin-dependent (type I) diabetes mellitus (IDDM) is polygenic. It has been shown that the absence of the aspartic acid in position 57 (Asp57) of the DQ beta chain is positively correlated to IDDM. However, Asp57-negative haplotypes do...

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Bibliografiske detaljer

Udgivet i:	J Clin Invest
Principais autores:	Khalil, I, d'Auriol, L, Gobet, M, Morin, L, Lepage, V, Deschamps, I, Park, M S, Degos, L, Galibert, F, Hors, J
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Clinical Investigation 1990
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296568/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2318983/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114569
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