Essential Role of NMDA Receptor Channel ε4 Subunit (GluN2D) in the Effects of Phencyclidine, but Not Methamphetamine

Phencyclidine (PCP), a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, increases locomotor activity in rodents and causes schizophrenia-like symptoms in humans. Although activation of the dopamine (DA) pathway is hypothesized to mediate these effects of PCP, the precise mechanisms by...

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Bibliographic Details
Main Authors: Hagino, Yoko, Kasai, Shinya, Han, Wenhua, Yamamoto, Hideko, Nabeshima, Toshitaka, Mishina, Masayoshi, Ikeda, Kazutaka
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965660/
https://ncbi.nlm.nih.gov/pubmed/21060893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013722
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