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Augmentation of the natriuretic activity of exogenous and endogenous atriopeptin in rats by inhibition of guanosine 3',5'-cyclic monophosphate degradation.

To investigate the relationship between AP, cyclic GMP, and sodium excretion, we studied the effect of a cyclic GMP phosphodiesterase inhibitor (M + B22948) on the natriuretic response to (a) an infusion of AP (103-126) and (b) acute volume expansion in rats. The phosphodiesterase inhibitor markedly...

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Xehetasun bibliografikoak
Argitaratua izan da:J Clin Invest
Egile Nagusiak: Wilkins, M R, Settle, S L, Needleman, P
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 1990
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296563/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2156897/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114564
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