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The Potential Use of Protein Kinase D Inhibitors for Prevention/Treatment of Epidermal Tumors
BACKGROUND: The serine/threonine kinase protein kinase D (PKD) has been proposed to be a pro-proliferative, anti-differentiative signal in epidermal keratinocytes. Indeed, the phorbol ester tumor promoter, 12-O-tetradecanoylphorbol 13-acetate (TPA) induces biphasic PKD activation, which mirrors the...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2965187/ https://ncbi.nlm.nih.gov/pubmed/20832999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jdermsci.2010.07.015 |
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