Acetylation pharmacogenetics. The slow acetylator phenotype is caused by decreased or absent arylamine N-acetyltransferase in human liver.

The biochemical basis underlying the genetic polymorphism of drug N-acetylation was investigated using a combination of in vivo and in vitro assays for arylamine N-acetyltransferase (NAT) activity and content in human liver. The acetylator phenotype of 26 surgical patients was determined using caffe...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Grant, D M, Mörike, K, Eichelbaum, M, Meyer, U A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296518/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2312737/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114527
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