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Pregnancy immunogenetics: NK cell education in the womb?

During embryo implantation and initiation of pregnancy, uterine NK (uNK) cells engage invasive fetal trophoblasts to remodel vessels that conduct blood to the placenta. This partnership, involving uNK cell receptors that recognize HLA-C ligands on trophoblasts, varies the course of human pregnancy b...

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Bibliographic Details
Main Authors: Parham, Peter, Guethlein, Lisbeth A.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964998/
https://ncbi.nlm.nih.gov/pubmed/20972330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44559
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