MHC-restricted fratricide of human lymphocytes expressing survivin-specific transgenic T cell receptors

The apoptosis inhibitor protein survivin is overexpressed in many tumors, making it a candidate target molecule for various forms of immunotherapy. To explore survivin as a target antigen for adoptive T cell therapy using lymphocytes expressing survivin-specific transgenic T cell receptors (Tg-TCRs)...

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Detalhes bibliográficos
Main Authors: Leisegang, Matthias, Wilde, Susanne, Spranger, Stefani, Milosevic, Slavoljub, Frankenberger, Bernhard, Uckert, Wolfgang, Schendel, Dolores J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964986/
https://ncbi.nlm.nih.gov/pubmed/20978348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43437
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