MAPK phosphatase–3 promotes hepatic gluconeogenesis through dephosphorylation of forkhead box O1 in mice

Insulin resistance results in dysregulated hepatic gluconeogenesis that contributes to obesity-related hyperglycemia and progression of type 2 diabetes mellitus (T2DM). Recent studies show that MAPK phosphatase–3 (MKP-3) promotes gluconeogenic gene transcription in hepatoma cells, but little is know...

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Detalhes bibliográficos
Main Authors: Wu, Zhidan, Jiao, Ping, Huang, Xueming, Feng, Bin, Feng, Yajun, Yang, Shengyong, Hwang, Phillip, Du, Jing, Nie, Yaohui, Xiao, Guozhi, Xu, Haiyan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964981/
https://ncbi.nlm.nih.gov/pubmed/20921625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43250
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