Endothelin-1 stimulates contraction of rat glomerular mesangial cells and potentiates beta-adrenergic-mediated cyclic adenosine monophosphate accumulation.

The newly isolated peptide, endothelin-1 (ET-1), is a potent pressor agent that reduces GFR and the glomerular ultrafiltration coefficient. Recent evidence demonstrates that ET-1 mobilizes intracellular Ca2+ [( Ca2+]i) in glomerular mesangial cells by activating the phosphoinositide cascade. The pre...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Simonson, M S, Dunn, M J
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1990
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296496/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2155927/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114505
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