The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer’s disease: a meta-analysis study

The only established genetic determinant of non-Mendelian forms of Alzheimer’s disease (AD) is the ε4 allele of the apolipoprotein E gene (APOE). Recently, it has been reported that the P86L polymorphism of the calcium homeostasis modulator 1 gene (CALHM1) is associated with the risk of developing A...

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Autori principali: Lambert, Jean-Charles, Sleegers, Kristel, González-Pérez, Antonio, Ingelsson, Martin, Beecham, Gary W, Hiltunen, Mikko, Combarros, Onofre, Bullido, Maria J, Brouwers, Nathalie, Bettens, Karolien, Berr, Claudine, Pasquier, Florence, Richard, Florence, DeKosky, Steven T, Hannequin, Didier, Haines, Jonathan L, Tognoni, Gloria, Fiévet, Nathalie, Dartigues, Jean-François, Tzourio, Christophe, Engelborghs, Sebastiaan, Arosio, Beatrice, Coto, Elicer, De Deyn, Peter, Zompo, Maria Del, Mateo, Ignacio, Boada, Merce, Antunez, Carmen, Lopez-Arrieta, Jesus, Epelbaum, Jacques, Schjeide, Brit-Maren Michaud, Frank-Garcia, Ana, Giedraitis, Vilmentas, Helisalmi, Seppo, Porcellini, Elisa, Pilotto, Alberto, Forti, Paola, Ferri, Raffaele, Delepine, Marc, Zelenika, Diana, Lathrop, Mark, Scarpini, Elio, Siciliano, Gabriele, Solfrizzi, Vincenzo, Sorbi, Sandro, Spalletta, Gianfranco, Ravaglia, Giovanni, Valdivieso, Fernando, Vepsäläinen, Saila, Alvarez, Victoria, Bosco, Paolo, Mancuso, Michelangelo, Panza, Francesco, Nacmias, Benedetta, Bossù, Paola, Hanon, Olivier, Piccardi, Paola, Annoni, Giorgio, Mann, David, Marambaud, Philippe, Seripa, Davide, Galimberti, Daniela, Tanzi, Rudolph E, Bertram, Lars, Lendon, Corinne, Lannfelt, Lars, Licastro, Federico, Campion, Dominique, Pericak-Vance, Margaret A, Soininen, Hilkka, Van Broeckhoven, Christine, Alpérovitch, Annick, Ruiz, Agustin, Kamboh, M Ilyas, Amouyel, Philippe
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964875/
https://ncbi.nlm.nih.gov/pubmed/20847397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2010-100933
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