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Fast Dissolving Sublingual Films of Ondansetron Hydrochloride: Effect of Additives on in vitro Drug Release and Mucosal Permeation

Ondansetron hydrochloride, a 5 HT3 antagonist is a powerful antiemetic drug which has oral bioavailability of 60% due to hepatic first pass metabolism and has a short half-life of 5 h. To overcome the above draw back, the present study was carried out to formulate and evaluate fast dissolving films...

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Bibliographic Details
Main Authors: Koland, M, Sandeep, VP, Charyulu, NR
Format: Artigo
Language:Inglês
Published: Medknow Publications 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964757/
https://ncbi.nlm.nih.gov/pubmed/21042474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/0975-1483.66790
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