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Origin and regulation of a disease-specific autoantibody response. Antigenic epitopes, spectrotype stability, and isotype restriction of anti-Jo-1 autoantibodies.

Anti-Jo-1 antibodies (AJoA), which bind to and inhibit the activity of histidyl-transfer RNA synthetase (HRS), are found in a genetically and clinically distinct subset of myositis patients. This specificity suggests that understanding the antigenic epitopes and immunoregulation governing the produc...

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Udgivet i:J Clin Invest
Principais autores: Miller, F W, Twitty, S A, Biswas, T, Plotz, P H
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1990
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296447/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1688885/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114461
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