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End-stage renal disease and diabetes catalyze the formation of a pentose-derived crosslink from aging human collagen.
Structure elucidation of a specific fluorophore from the aging extracellular matrix revealed the presence of a protein crosslink formed through nonenzymatic glycosylation of lysine and arginine residues. The unexpected finding that a pentose instead of a hexose is involved in the crosslinking proces...
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| Published in: | J Clin Invest |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Clinical Investigation
1990
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296435/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2298912/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114449 |
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