The Human Host Defense Peptide LL-37 Interacts with Neisseria meningitidis Capsular Polysaccharides and Inhibits Inflammatory Mediators Release

Capsular polysaccharides (CPS) are a major virulence factor in meningococcal infections and form the basis for serogroup designation and protective vaccines. Our work has identified meningococcal CPS as a pro-inflammatory ligand that functions through TLR2 and TLR4-MD2-dependent activation. We hypot...

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Hlavní autoři: Zughaier, Susu M., Svoboda, Pavel, Pohl, Jan, Stephens, David S., Shafer, William M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2010
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964311/
https://ncbi.nlm.nih.gov/pubmed/21049021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013627
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