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An actin-regulated importin α/β-dependent extended bipartite NLS directs nuclear import of MRTF-A
Myocardin-related transcription factors (MRTFs) are actin-regulated transcriptional coactivators, which bind G-actin through their N-terminal RPEL domains. In response to signal-induced actin polymerisation and concomitant G-actin depletion, MRTFs accumulate in the nucleus and activate target gene t...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2964165/ https://ncbi.nlm.nih.gov/pubmed/20818336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.216 |
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