Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance.

Familial glucocorticoid resistance is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations in the absence of stigmata of Cushing's syndrome. Our previous studies of the first reported kindred showed a two- to threefold reduction in glucocorticoid rec...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Hurley, D M, Accili, D, Stratakis, C A, Karl, M, Vamvakopoulos, N, Rorer, E, Constantine, K, Taylor, S I, Chrousos, G P
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 1991
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296359/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1704018/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115046
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