γ-Tocotrienol but Not γ-Tocopherol Blocks STAT3 Cell Signaling Pathway through Induction of Protein-tyrosine Phosphatase SHP-1 and Sensitizes Tumor Cells to Chemotherapeutic Agents

Although γ-tocotrienol (T3), a vitamin E isolated primarily from palm and rice bran oil, has been linked with anticancer activities, the mechanism of this action is poorly understood. In this study, we investigated whether γ-T3 can modulate the STAT3 cell signaling pathway, closely linked to inflamm...

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Bibliographic Details
Main Authors: Kannappan, Ramaswamy, Yadav, Vivek R., Aggarwal, Bharat B.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963373/
https://ncbi.nlm.nih.gov/pubmed/20720018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.158378
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