Mechanism of compensatory hyperinsulinemia in normoglycemic insulin-resistant spontaneously hypertensive rats. Augmented enzymatic activity of glucokinase in beta-cells.

The cause of compensatory hyperinsulinemia in normoglycemic insulin-resistant states is unknown. Using spontaneously hypertensive rats (SHR), we tested the hypothesis that a lowered beta-cell set-point for glucose causes a hypersecretion of insulin at a normal glucose level. Islets isolated from nor...

Täydet tiedot

Bibliografiset tiedot

Julkaisussa:	J Clin Invest
Päätekijät:	Chen, C, Hosokawa, H, Bumbalo, L M, Leahy, J L
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	American Society for Clinical Investigation 1994
Aiheet:	Research Article
Linkit:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296322/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8040280/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117335
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