Progesterone and allopregnanolone attenuate blood-brain barrier dysfunction following permanent focal ischemia by regulating the expression of matrix metalloproteinases

Blood-brain barrier (BBB) breakdown after stroke is linked to the up-regulation of metalloproteinases (MMPs) and inflammation. This study examines the effects of progesterone (PROG) and its neuroactive metabolite allopregnanolone (ALLO) on BBB integrity following permanent middle cerebral artery occ...

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Hlavní autoři: Ishrat, Tauheed, Sayeed, Iqbal, Atif, Fahim, Hua, Fang, Stein, Donald G.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963070/
https://ncbi.nlm.nih.gov/pubmed/20816826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2010.08.023
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