Negative feedback regulation of pulsatile growth hormone secretion by insulin-like growth factor I. Involvement of hypothalamic somatostatin.

To investigate the mechanisms of the negative feedback inhibition of growth hormone (GH) secretion by IGF-I, we studied parameters of GH pulsatility in six normal, fed men before and during a 48-h infusion of recombinant human IGF-I (rhIGF-I) (10-15 micrograms/kg per h). Plasma levels of IGF-I incre...

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Опубликовано в::	J Clin Invest
Главные авторы:	Bermann, M, Jaffe, C A, Tsai, W, DeMott-Friberg, R, Barkan, A L
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Clinical Investigation 1994
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296291/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7913710/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117299
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