Changes in cartilage metabolism in arthritis are reflected by altered serum and synovial fluid levels of the cartilage proteoglycan aggrecan. Implications for pathogenesis.

The metabolism of the cartilage proteoglycan aggrecan was studied in patients with osteoarthritis (OA, n = 83), rheumatoid arthritis (RA, n = 127), and in controls (n = 117) using monoclonal antibody-based radioimmunoassays for glycosaminoglycans in the serum and synovial fluid (SF) to detect epitop...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Poole, A R, Ionescu, M, Swan, A, Dieppe, P A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1994
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296278/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7518830/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117314
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