Polycystin-2 Activity Is Controlled by Transcriptional Coactivator with PDZ Binding Motif and PALS1-associated Tight Junction Protein

Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent monogenic cause of kidney failure, characterized by the development of renal cysts. ADPKD is caused by mutations of the polycystin-1 (PC1) or polycystin-2 (PC2) genes. PC2 encodes a Ca(2+)-permeable cation channel, and its dys...

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Main Authors: Duning, Kerstin, Rosenbusch, Deike, Schlüter, Marc A., Tian, Yuemin, Kunzelmann, Karl, Meyer, Nina, Schulze, Ulf, Markoff, Arseni, Pavenstädt, Hermann, Weide, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2962456/
https://ncbi.nlm.nih.gov/pubmed/20833712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C110.146381
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