Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis.

Experiments were designed to test the hypothesis that chronic exposure to tumor necrosis factor alpha (TNF) alters the function of activated T lymphocytes. Pretreatment of tetanus toxoid-specific T cell clones with TNF for up to 16 d impaired rechallenge proliferative responses to antigen in a dose-...

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Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Cope, A P, Londei, M, Chu, N R, Cohen, S B, Elliott, M J, Brennan, F M, Maini, R N, Feldmann, M
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1994
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC296155/
https://ncbi.nlm.nih.gov/pubmed/8040330
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