The necrotic venom of the brown recluse spider induces dysregulated endothelial cell-dependent neutrophil activation. Differential induction of GM-CSF, IL-8, and E-selectin expression.

Brown recluse spider (Loxosceles reclusa) venom induces severe dermonecrotic lesions. The mechanism for this is unknown but presents an interesting paradox: necrosis is completely dependent on the victim's neutrophils, yet neutrophils are not activated by the venom. We show Loxosceles venom is a pot...

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Bibliografiske detaljer

Udgivet i:	J Clin Invest
Principais autores:	Patel, K D, Modur, V, Zimmerman, G A, Prescott, S M, McIntyre, T M
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Clinical Investigation 1994
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296140/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7518841/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117379
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