Anti-nucleosome antibodies complexed to nucleosomal antigens show anti-DNA reactivity and bind to rat glomerular basement membrane in vivo.

Histones can mediate the binding of DNA and anti-DNA to the glomerular basement membrane (GBM). In ELISA histone/DNA/anti-DNA complexes are able to bind to heparan sulfate (HS), an intrinsic constituent of the GBM. We questioned whether histone containing immune complexes are able to bind to the GBM...

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Bibliografiske detaljer
Main Authors: Kramers, C, Hylkema, M N, van Bruggen, M C, van de Lagemaat, R, Dijkman, H B, Assmann, K J, Smeenk, R J, Berden, J H
Format: Artigo
Sprog:Inglês
Udgivet: 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC296132/
https://ncbi.nlm.nih.gov/pubmed/8040312
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