Immunoprotective Activity and Safety of a Respiratory Syncytial Virus Vaccine: Mucosal Delivery of Fusion Glycoprotein with a CpG Oligodeoxynucleotide Adjuvant

CpG oligodeoxynucleotides (ODN) were identified that stimulated immunoglobulin production and cell proliferation in cotton rat cells in vitro. Three of these ODN were used as a mucosal adjuvant in the noses of cotton rats immunized via this route with respiratory syncytial virus fusion (F) protein....

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Prince, Gregory A., Mond, James J., Porter, David D., Yim, Kevin C., Lan, Steve J., Klinman, Dennis M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2003
Assuntos:	Vaccines and Antiviral Agents
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296064/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14645572/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.24.13156-13160.2003
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