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Human appendix B cells naturally express receptors for and respond to interleukin 6 with selective IgA1 and IgA2 synthesis.

Past studies have shown that freshly isolated human B cells from peripheral blood and tonsils do not express IL-6 receptors (IL-6R); however, mitogen or antigen activation of these B cells induces IL-6R and responsiveness to IL-6. In this study, we have shown that a high proportion of B cells enzyma...

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Udgivet i:J Clin Invest
Principais autores: Fujihashi, K, McGhee, J R, Lue, C, Beagley, K W, Taga, T, Hirano, T, Kishimoto, T, Mestecky, J, Kiyono, H
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1991
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296026/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2056119/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115284
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