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Effect of neutrophil elastase and its inhibitor EPI-hNE4 on transepithelial sodium transport across normal and cystic fibrosis human nasal epithelial cells
BACKGROUND: Hyperactivity of the epithelial sodium (Na(+)) channel (ENaC) and increased Na(+ )absorption by airway epithelial cells leading to airway surface liquid dehydration and impaired mucociliary clearance are thought to play an important role in the pathogenesis of cystic fibrosis (CF) pulmon...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2959028/ https://ncbi.nlm.nih.gov/pubmed/20932306 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-11-141 |
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