A new variant of Glanzmann's thrombasthenia (Strasbourg I). Platelets with functionally defective glycoprotein IIb-IIIa complexes and a glycoprotein IIIa 214Arg----214Trp mutation.

We describe a new variant of Glanzmann's thrombasthenia (variant Strasbourg I). The patient (M.S.) showed an absence of platelet aggregation to ADP, thrombin, and collagen, and a decreased clot retraction. Platelet fibrinogen was approximately 20% of normal levels. ADP-stimulated platelets boun...

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Опубликовано в: :J Clin Invest
Главные авторы: Lanza, F, Stierlé, A, Fournier, D, Morales, M, André, G, Nurden, A T, Cazenave, J P
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 1992
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295902/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1602006/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115808
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