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Phagocytosis and LPS alter the maturation state of β-amyloid precursor protein and induce different Aβ peptide release signatures in human mononuclear phagocytes
BACKGROUND: The classic neuritic β-amyloid plaque of Alzheimer's disease (AD) is typically associated with activated microglia and neuroinflammation. Similarly, cerebrovascular β-amyloid (Aβ) deposits are surrounded by perivascular macrophages. Both observations indicate a contribution of the m...
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Main Authors: | , , , , , , , |
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格式: | Artigo |
語言: | Inglês |
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BioMed Central
2010
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在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2958903/ https://ncbi.nlm.nih.gov/pubmed/20929546 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-7-59 |
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