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Genetic Variations in Human Glutathione Transferase Enzymes: Significance for Pharmacology and Toxicology

Glutathione transferase enzymes (GSTs) catalyze reactions in which electrophiles are conjugated to the tripeptide thiol glutathione. While many GST-catalyzed transformations result in the detoxication of xenobiotics, a few substrates, such as dihaloalkanes, undergo bioactivation to reactive intermed...

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Detalhes bibliográficos
Autor principal: Josephy, P. David
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE-Hindawi Access to Research 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2958679/
https://ncbi.nlm.nih.gov/pubmed/20981235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2010/876940
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