Effect of the I(to) activator NS5806 on cloned K(v)4 channels depends on the accessory protein KChIP2

BACKGROUND AND PURPOSE: The compound NS5806 increases the transient outward current (I(to)) in canine ventricular cardiomyocytes and slows current decay. In human and canine ventricle, I(to) is thought to be mediated by K(V)4.3 and various ancillary proteins, yet, the exact subunit composition of I(...

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Detalhes bibliográficos
Main Authors: Lundby, A, Jespersen, T, Schmitt, N, Grunnet, M, Olesen, S-P, Cordeiro, JM, Calloe, K
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2010
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2958647/
https://ncbi.nlm.nih.gov/pubmed/20649599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00859.x
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