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Engineering host cell lines to reduce terminal sialylation of secreted antibodies
Covalently-linked glycans on proteins have many functional roles, some of which are still not completely understood. Antibodies have a very specific glycan modification in the Fc region that is required for mediating immune effector functions. These Fc glycans are typically highly heterogeneous in s...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Landes Bioscience
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2958573/ https://ncbi.nlm.nih.gov/pubmed/20716959 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.2.5.13078 |
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