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Solid-state NMR and SAXS studies provide a structural basis for the activation of αB-crystallin oligomers

The small heat shock protein αB-crystallin (αB) contributes to cellular protection against stress. For decades, high-resolution structural studies on oligomeric αB have been confounded by its polydisperse nature. Here, we present a structural basis of oligomer assembly and activation of the chaperon...

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Bibliografiske detaljer
Main Authors: Jehle, Stefan, Rajagopal, Ponni, Bardiaux, Benjamin, Markovic, Stefan, Kühne, Ronald, Stout, Joseph R, Higman, Victoria A, Klevit, Rachel E, van Rossum, Barth-Jan, Oschkinat, Hartmut
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957905/
https://ncbi.nlm.nih.gov/pubmed/20802487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1891
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