Fast (18)F Labeling of a Near-Infrared Fluorophore Enables Positron Emission Tomography and Optical Imaging of Sentinel Lymph Nodes

We combine a novel boronate trap for F(−) with a near-infrared fluorophore into a single molecule. Attachment to targeting ligands enables localization by positron emission tomography (PET) and near-infrared fluorescence (NIRF). Our first application of this generic tag is to label Lymphoseek (tilma...

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Main Authors: Ting, Richard, Aguilera, Todd A., Crisp, Jessica L., Hall, David J., Eckelman, William C., Vera, David R., Tsien, Roger Y.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2010
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957852/
https://ncbi.nlm.nih.gov/pubmed/20873712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc1001328
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