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Synthesis of Biologically Active Biotinylated Muramyl Dipeptides

Muramyl dipeptide (MDP) is believed to interact with an innate immune receptor, Nod2. To identify the cellular receptor for MDP, we have synthesized biotinylated MDP isomers and tested the ability of these compounds to activate Nod2 in a cell-based assay. We found that the modification of MDP does n...

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Detalhes bibliográficos
Main Authors: Grimes, Catherine Leimkuhler, Podolsky, Daniel K, O'Shea, Erin K
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957841/
https://ncbi.nlm.nih.gov/pubmed/20822907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.08.056
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