Asialoagalacto-human chorionic gonadotropin, a carbohydrate-modified variant of human chorionic gonadotropin, antagonizes the stimulatory actions of bovine thyroid-stimulating hormone on thyroid function and HLA-DR expression in human thyroid in vitro and in vivo.

The concept of using thyroid-stimulating hormone (TSH) receptor antagonists in the management of Graves' disease is intriguing. Therefore, we investigated a TSH receptor antagonist derived from human chorionic gonadotropin (hCG) with respect to TSH receptor binding, adenylate cyclase activity,...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Hoermann, R, Schumm-Draeger, P M, Rehbach, K, Mann, K
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1991
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295774/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1752954/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115519
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