Gene Expression of Endothelin-1 and Endothelin Receptor A on Monocrotaline-Induced Pulmonary Hypertension in Rats After Bosentan Treatment

BACKGROUND AND OBJECTIVES: Endothelin (ET)-1, a potent endothelium-derived vasoconstrictor peptide, has a potential pathophysiologic role in pulmonary hypertension. Bosentan, a dual ET receptor (ET(A)/ET(B)) antagonist, is efficacious in treatment of pulmonary hypertension. The objectives of this st...

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Hlavní autoři: Lim, Kyoung Ah, Kim, Kwan Chang, Cho, Min-Sun, Lee, Bo En, Kim, Hae Soon, Hong, Young Mi
Médium: Artigo
Jazyk:Inglês
Vydáno: The Korean Society of Cardiology 2010
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957645/
https://ncbi.nlm.nih.gov/pubmed/20967148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4070/kcj.2010.40.9.459
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