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Interferon-γ Is Induced in Human Peripheral Blood Immune Cells In Vitro by Sodium Stibogluconate/Interleukin-2 and Mediates Its Antitumor Activity In Vivo

Sodium stibogluconate (SSG), an inhibitor of SHP-1 that negatively regulates cytokine signaling and immunity, suppressed growth of murine Renca tumors in combination with interleukin-2 (IL-2) via a T-cell-dependent mechanism. The ability of SSG to interact with IL-2 in activating primary human immun...

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Bibliografske podrobnosti
Main Authors: Fan, Keke, Borden, Ernest, Yi, Taolin
Format: Artigo
Jezik:Inglês
Izdano: Mary Ann Liebert, Inc. 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956636/
https://ncbi.nlm.nih.gov/pubmed/19514839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jir.2008.0061
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