Alkaline phosphatase: placental and tissue-nonspecific isoenzymes hydrolyze phosphoethanolamine, inorganic pyrophosphate, and pyridoxal 5'-phosphate. Substrate accumulation in carriers of hypophosphatasia corrects during pregnancy.

Hypophosphatasia features selective deficiency of activity of the tissue-nonspecific (liver/bone/kidney) alkaline phosphatase (ALP) isoenzyme (TNSALP); placental and intestinal ALP isoenzyme (PALP and IALP, respectively) activity is not reduced. Three phosphocompounds (phosphoethanolamine [PEA], ino...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Whyte, M P, Landt, M, Ryan, L M, Mulivor, R A, Henthorn, P S, Fedde, K N, Mahuren, J D, Coburn, S P
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295625/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7706447/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117814
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