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Renal cancer resistance to antiangiogenic therapy is delayed by restoration of angiostatic signaling

Treatment of metastatic renal cell cancer (RCC) with antiangiogenic agents that block vascular endothelial growth factor (VEGF) receptor 2 signaling produces tumor regression in a substantial fraction of patients; however resistance typically develops within 6–12 months. The purpose of this study wa...

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Detalhes bibliográficos
Main Authors: Bhatt, Rupal S., Wang, Xiaoen, Zhang, Liang, Collins, Michael P., Signoretti, Sabina, Alsop, David C., Goldberg, S. Nahum, Atkins, Michael B., Mier, James W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956167/
https://ncbi.nlm.nih.gov/pubmed/20699227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0477
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