AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia

BACKGROUND: Children with Acute Lymphoblastic Leukemia (ALL) diagnosed with resistant phenotypes and those who relapse have a dismal prognosis for cure. In search for novel treatment strategies, we identified the AMP activated protein kinase (AMPK) as a potential drug target based on its effects on...

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Autors principals: Leclerc, Gilles M, Leclerc, Guy J, Fu, Guilian, Barredo, Julio C
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955666/
https://ncbi.nlm.nih.gov/pubmed/20863384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-2187-5-15
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