Chemistry and Pharmacology of Nicotinic Ligands Based on 6-[5-(Azetidin-2-ylmethoxy) pyridin-3-yl]hex-5-yn-1-ol (AMOP-H-OH) for Possible Use in Depression

AMOP-H-OH (6-[5-(azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol) and some of its sulfur-bearing analogs were tested for their actions in vitro at human α4β2-, α4β4-, α3β4*- and α1*-nicotinic acetylcholine receptors (nAChRs). AMOP-H-OH also was assessed in a model of antidepressant efficacy. AMOP-H-...

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Autori principali: Kozikowski, Alan P., Eaton, J. Brek, Bajjuri, Krishna Mohan, Chellappan, Sheela K., Chen, Yihua, Karadi, Sudhakar, He, Rong, Caldarone, Barbara, Manzano, Michael, Yuen, Powai, Lukas, Ronald J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955514/
https://ncbi.nlm.nih.gov/pubmed/19569163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.200900079
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