Pulsed Electron Spin Resonance Resolves the Coordination Site of Cu(2+) Ions in α1-Glycine Receptor

Herein, we identify the coordination environment of Cu(2+) in the human α1-glycine receptor (GlyR). GlyRs are members of the pentameric ligand-gated ion channel superfamily (pLGIC) that mediate fast signaling at synapses. Metal ions like Zn(2+) and Cu(2+) significantly modulate the activity of pLGIC...

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Detalhes bibliográficos
Main Authors: Ruthstein, Sharon, Stone, Katherine M., Cunningham, Timothy F., Ji, Ming, Cascio, Michael, Saxena, Sunil
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2010
Assuntos:
Channels and Transporters
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955494/
https://ncbi.nlm.nih.gov/pubmed/20959090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.08.050
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