Cellular and molecular events leading to mitochondrial toxicity of 1-(2-deoxy-2-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil in human liver cells.

We have explored the mechanism(s) related to FIAU-induced liver toxicity, particularly focusing on its effect on mitochondrial function in a human hepatoma cell line-HepG2. The potential role of FMAU and FAU, metabolites detected in FIAU-treated patients were also ascertained. FIAU and FMAU inhibite...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Cui, L, Yoon, S, Schinazi, R F, Sommadossi, J P
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295512/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7860738/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117698
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