Structure, function, and folding of phosphoglycerate kinase are strongly perturbed by macromolecular crowding

We combine experiment and computer simulation to show how macromolecular crowding dramatically affects the structure, function, and folding landscape of phosphoglycerate kinase (PGK). Fluorescence labeling shows that compact states of yeast PGK are populated as the amount of crowding agents (Ficoll...

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Detalhes bibliográficos
Main Authors: Dhar, Apratim, Samiotakis, Antonios, Ebbinghaus, Simon, Nienhaus, Lea, Homouz, Dirar, Gruebele, Martin, Cheung, Margaret S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955104/
https://ncbi.nlm.nih.gov/pubmed/20921368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006760107
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