Structure, function, and folding of phosphoglycerate kinase are strongly perturbed by macromolecular crowding

We combine experiment and computer simulation to show how macromolecular crowding dramatically affects the structure, function, and folding landscape of phosphoglycerate kinase (PGK). Fluorescence labeling shows that compact states of yeast PGK are populated as the amount of crowding agents (Ficoll...

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Détails bibliographiques
Auteurs principaux: Dhar, Apratim, Samiotakis, Antonios, Ebbinghaus, Simon, Nienhaus, Lea, Homouz, Dirar, Gruebele, Martin, Cheung, Margaret S.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2010
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955104/
https://ncbi.nlm.nih.gov/pubmed/20921368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006760107
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