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Structure, function, and folding of phosphoglycerate kinase are strongly perturbed by macromolecular crowding
We combine experiment and computer simulation to show how macromolecular crowding dramatically affects the structure, function, and folding landscape of phosphoglycerate kinase (PGK). Fluorescence labeling shows that compact states of yeast PGK are populated as the amount of crowding agents (Ficoll...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2955104/ https://ncbi.nlm.nih.gov/pubmed/20921368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006760107 |
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